Retatrutide 10 mg
GLP-1 · GIP · Glucagon
One of the most talked-about peptides right now. Retatrutide targets three of the body’s own hormones that play a role in appetite, satiety and blood sugar.
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Intended solely for laboratory and research purposes. Not for human or animal consumption.
What is retatrutide?
Retatrutide was developed by Eli Lilly, the company behind tirzepatide. Whereas semaglutide acts on one hormone (GLP-1) and tirzepatide on two (GLP-1 and GIP), retatrutide acts on three: GLP-1, GIP and glucagon. Researchers therefore call it a triple agonist; online you’ll also come across the nickname "triple G".
How does retatrutide work?
After eating, your body makes its own hormones that regulate your appetite, satiety and blood sugar. Retatrutide mimics three of them at once. In research, this combination leads to less hunger, feeling full for longer and higher energy expenditure. That’s why it is so interesting for research into weight and blood sugar.
A gut hormone released after eating. It signals "I’m full" to your brain, makes your stomach empty more slowly and helps produce insulin when your blood sugar rises. Ozempic (semaglutide) acts on this hormone.
Also a gut hormone released after eating. It enhances the effect of GLP-1 on insulin and plays a role in how your body stores fat. Mounjaro (tirzepatide) acts on both GLP-1 and GIP.
A hormone from the pancreas and the counterpart to insulin: it makes your liver release sugar. It is of interest in research because it also appears to increase energy expenditure and fat burning in the liver.
How did retatrutide become known?
In June 2023, the results of the phase 2 study were published in The New England Journal of Medicine. Participants with obesity on the highest dose lost an average of around 24% of their body weight after 48 weeks. Figures like these had never been seen before with comparable compounds, and retatrutide was instantly on the map.
What is retatrutide being researched for?
Mainly obesity and overweight and type 2 diabetes, with a focus on weight loss and better blood sugar regulation. There are also studies in conditions often linked to excess weight, such as knee osteoarthritis and sleep apnoea.
In the large phase 3 study TRIUMPH-2 (The Lancet, 2026), participants with obesity and type 2 diabetes lost an average of 11.9% to 18.8% of their weight after 80 weeks, compared with 5.1% on placebo. Read the study summary.
Is retatrutide approved?
Not yet. Retatrutide is a research compound and is not (yet) approved as a medicine. That’s why SolidPep supplies it for research only: as a powder in a sealed vial, at least 99% pure.
Technical data
For those who want the details. Every batch comes with a test report.
| Other name | LY3437943 |
|---|---|
| Length | 39 amino acids |
| Formula | C221H342N46O68 |
| Molecular weight | ± 4731.3 g/mol |
| Form | Powder, freeze-dried (lyophilised) |
| Purity | At least 99%, tested with HPLC |
| Packaging | Sealed glass vial |
| Storage | In the fridge (2–8 °C), dark. For longer storage: in the freezer (−20 °C) |
| Test report (CoA) | Per batch, on request |
Frequently asked questions about Retatrutide
What is retatrutide?
A peptide from Eli Lilly that acts on three hormones at once: GLP-1, GIP and glucagon. That’s why it’s called a triple agonist.
What is retatrutide being researched for?
Mainly obesity and type 2 diabetes, with a focus on weight loss and blood sugar regulation. Studies are also under way in knee osteoarthritis and sleep apnoea.
How does retatrutide work?
Retatrutide mimics three of the body’s own hormones at once: GLP-1, GIP and glucagon. In research, this leads to less hunger, feeling full for longer and higher energy expenditure.
What is GLP-1?
A hormone from your gut that is released after eating. It makes you feel full, makes your stomach empty more slowly and helps produce insulin.
What is GIP?
Also a gut hormone released after eating. It enhances the effect of GLP-1 on insulin and plays a role in how your body stores fat.
What is glucagon?
A hormone from the pancreas and the counterpart to insulin: it makes your liver release sugar. It also appears to increase energy expenditure.
How does it differ from Ozempic and Mounjaro?
Ozempic (semaglutide) acts on one hormone: GLP-1. Mounjaro (tirzepatide) acts on two: GLP-1 and GIP. Retatrutide acts on three: GLP-1, GIP and glucagon.
Is retatrutide approved?
No, not yet. It is a research compound and is not (yet) approved as a medicine.
How do you prepare retatrutide for research?
You dissolve the powder in bacteriostatic water, then store the solution in the fridge. Want it explained step by step, including sterile technique and calculating concentrations? Book a research consultation.
How do you store retatrutide?
Store the vial in the fridge (2–8 °C), in the dark. For longer periods, it can go in the freezer (−20 °C).
More questions about ordering, shipping and storage · Peptide calculator: concentration after reconstitution
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